Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to...

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Publicado en:eLife
Autores principales: Backman, Lindsey RF, Huang, Yolanda Y, Andorfer, Mary C, Gold, Brian, Raines, Ronald T, Balskus, Emily P, Drennan, Catherine L
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077986/
https://ncbi.nlm.nih.gov/pubmed/32180548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51420
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