1α,20S-Dihydroxyvitamin D(3) Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

1α,20S-Dihydroxyvitamin D3 [1,20S(OH)(2)D(3)], a natural and bioactive vitamin D3 metabolite, was chemically synthesized for the first time. X-ray crystallography analysis of intermediate 15 confirmed its 1α-OH configuration. 1,20S(OH)(2)D(3) interacts with the vitamin D receptor (VDR), with similar...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lin, Zongtao, Chen, Hao, Belorusova, Anna Y., Bollinger, John C., Tang, Edith K. Y., Janjetovic, Zorica, Kim, Tae-Kang, Wu, Zhongzhi, Miller, Duane D., Slominski, Andrzej T., Postlethwaite, Arnold E., Tuckey, Robert C., Rochel, Natacha, Li, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579064/
https://ncbi.nlm.nih.gov/pubmed/28860545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10917-7
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