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Bcl6 Promotes Follicular Helper T Cell Differentiation and PD-1 Expression in a Blimp1-independent Manner

The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (T(FH)) cells: Bcl6 promotes and Blimp1 inhibits T(FH) cell differentiation. Similarly, Bcl6 activates, while Blimp1 represses, expression of the T(FH) cell marker PD-1. However, Bcl6 and Blim...

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Bibliografiske detaljer
Udgivet i:Eur J Immunol
Main Authors: Xie, Markus M., Koh, Byung-Hee, Hollister, Kristin, Wu, Hao, Sun, Jie, Kaplan, Mark H., Dent, Alexander L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578616/
https://ncbi.nlm.nih.gov/pubmed/28586108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747034
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