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T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria
Hybrid Th1/Tfh cells (IFN-γ(+)IL-21(+)CXCR5(+)) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ(+) T cells control parasitemia, whereas antibody and IL-21(+)Bcl6(+) T cells effect final clearance, suggesting an evolutionary driver for the hybrid popu...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7339051/ https://ncbi.nlm.nih.gov/pubmed/32634740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101310 |
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