Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression

Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Hand2 (GHMT) directly reprogram fibroblasts into cardiomyocyte-like cells (iCMs). However, the critical timing of transgene expression a...

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Publié dans:Int J Mol Sci
Auteurs principaux: Umei, Tomohiko C., Yamakawa, Hiroyuki, Muraoka, Naoto, Sadahiro, Taketaro, Isomi, Mari, Haginiwa, Sho, Kojima, Hidenori, Kurotsu, Shota, Tamura, Fumiya, Osakabe, Rina, Tani, Hidenori, Nara, Kaori, Miyoshi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578192/
https://ncbi.nlm.nih.gov/pubmed/28825623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18081805
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