Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting that undefined extrinsic factors may regulate cardiac reprogramming. Previous in vitro st...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Kurotsu, Shota, Sadahiro, Taketaro, Fujita, Ryo, Tani, Hidenori, Yamakawa, Hiroyuki, Tamura, Fumiya, Isomi, Mari, Kojima, Hidenori, Yamada, Yu, Abe, Yuto, Murakata, Yoshiko, Akiyama, Tatsuya, Muraoka, Naoto, Harada, Ichiro, Suzuki, Takeshi, Fukuda, Keiichi, Ieda, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486305/
https://ncbi.nlm.nih.gov/pubmed/32857980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.07.022
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