Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression

Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Hand2 (GHMT) directly reprogram fibroblasts into cardiomyocyte-like cells (iCMs). However, the critical timing of transgene expression a...

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Detalhes bibliográficos
Main Authors: Tomohiko C. Umei, Hiroyuki Yamakawa, Naoto Muraoka, Taketaro Sadahiro, Mari Isomi, Sho Haginiwa, Hidenori Kojima, Shota Kurotsu, Fumiya Tamura, Rina Osakabe, Hidenori Tani, Kaori Nara, Hiroyuki Miyoshi, Keiichi Fukuda, Masaki Ieda
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-08-01
Colecção:International Journal of Molecular Sciences
Assuntos:
reprogramming
cardiomyocyte
doxycycline-inducible
cell cycle
fibroblast
Acesso em linha:https://www.mdpi.com/1422-0067/18/8/1805
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