Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer

The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Nieskoski, Michael D., Marra, Kayla, Gunn, Jason R., Hoopes, P. Jack, Doyley, Marvin M., Hasan, Tayyaba, Trembly, B. Stuart, Pogue, Brian W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577321/
https://ncbi.nlm.nih.gov/pubmed/28855644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10671-w
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