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Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer
The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5577321/ https://ncbi.nlm.nih.gov/pubmed/28855644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10671-w |
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