Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer

The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nieskoski, Michael D., Marra, Kayla, Gunn, Jason R., Hoopes, P. Jack, Doyley, Marvin M., Hasan, Tayyaba, Trembly, B. Stuart, Pogue, Brian W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577321/
https://ncbi.nlm.nih.gov/pubmed/28855644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10671-w
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