RECQL4 promotes DNA end resection in repair of DNA double-strand breaks

The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome stability, aging and cancer. Here, we identify a crucial role for RECQL4 in DNA end resection, which is the initial and an essential step of homologous recombination (HR)-dependent DNA double-strand break repair (DSBR)....

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Lu, Huiming, Shamanna, Raghavendra A., Keijzers, Guido, Anand, Roopesh, Rasmussen, Lene Juel, Cejka, Petr, Croteau, Deborah L., Bohr, Vilhelm A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576896/
https://ncbi.nlm.nih.gov/pubmed/27320928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.079
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