Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome, promotes the two major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). Here we report that...

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Pubblicato in:Nat Commun
Autori principali: Lu, Huiming, Shamanna, Raghavendra A., de Freitas, Jessica K., Okur, Mustafa, Khadka, Prabhat, Kulikowicz, Tomasz, Holland, Priscella P., Tian, Jane, Croteau, Deborah L., Davis, Anthony J., Bohr, Vilhelm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725494/
https://ncbi.nlm.nih.gov/pubmed/29229926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02146-3
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