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The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV‑1 gp41 by Displacement of the C-Terminal Helical Repeat Region
The conformational transition of the core domain of HIV-1 gp41 from a prehairpin intermediate to a six-helix bundle is responsible for virus–cell fusion. Several inhibitors which target the N-heptad repeat helical coiled-coil trimer that is fully accessible in the prehairpin intermediate have been d...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5576721/ https://ncbi.nlm.nih.gov/pubmed/26506247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01021 |
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