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Evidence That the Transition of HIV-1 Gp41 into a Six-Helix Bundle, Not the Bundle Configuration, Induces Membrane Fusion

Many viral fusion proteins exhibit a six-helix bundle as a core structure. HIV Env–induced fusion was studied to resolve whether membrane merger was due to the transition into the bundle configuration or occurred after bundle formation. Suboptimal temperature was used to arrest fusion at an intermed...

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Autores principales: Melikyan, Grigory B., Markosyan, Ruben M., Hemmati, Hila, Delmedico, Mary K., Lambert, Dennis M., Cohen, Fredric S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192659/
https://ncbi.nlm.nih.gov/pubmed/11038187
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