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The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV‑1 gp41 by Displacement of the C-Terminal Helical Repeat Region

The conformational transition of the core domain of HIV-1 gp41 from a prehairpin intermediate to a six-helix bundle is responsible for virus–cell fusion. Several inhibitors which target the N-heptad repeat helical coiled-coil trimer that is fully accessible in the prehairpin intermediate have been d...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Louis, John M., Baber, James L., Clore, G. Marius
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576721/
https://ncbi.nlm.nih.gov/pubmed/26506247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01021
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