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Oligo(lactic acid)(n)-paclitaxel prodrugs for poly(ethylene glycol)-block-poly(lactic acid) micelles: Loading, release and backbiting conversion for anticancer activity
Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles are nanocarriers for poorly water-soluble anticancer agents and have advanced paclitaxel (PTX) into humans due to drug solubilization, biocompatibility and dose escalation. However, PEG-b-PLA micelles rapidly release PTX, resulti...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5576186/ https://ncbi.nlm.nih.gov/pubmed/27374999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03995 |
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