Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity

PURPOSE: Develop a Cremophor(®) and solvent free formulation of paclitaxel using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) and characterize their release, solubility, cytotoxicity, tolerability, and disposition. METHODS: Hydrophobic prodrugs of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Forrest, M. Laird, Yáñez, Jaime A., Remsberg, Connie M., Ohgami, Yusuke, Kwon, Glen S., Davies, Neal M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872624/
https://ncbi.nlm.nih.gov/pubmed/17912488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9451-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados