Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity

PURPOSE: Develop a Cremophor(®) and solvent free formulation of paclitaxel using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) and characterize their release, solubility, cytotoxicity, tolerability, and disposition. METHODS: Hydrophobic prodrugs of...

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Udgivet i:Pharm Res
Main Authors: Forrest, M. Laird, Yáñez, Jaime A., Remsberg, Connie M., Ohgami, Yusuke, Kwon, Glen S., Davies, Neal M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872624/
https://ncbi.nlm.nih.gov/pubmed/17912488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9451-9
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