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Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity
PURPOSE: Develop a Cremophor(®) and solvent free formulation of paclitaxel using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) and characterize their release, solubility, cytotoxicity, tolerability, and disposition. METHODS: Hydrophobic prodrugs of...
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| Udgivet i: | Pharm Res |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4872624/ https://ncbi.nlm.nih.gov/pubmed/17912488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9451-9 |
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