Formulation of a Geldanamycin Prodrug in mPEG-b-PCL Micelles Greatly Enhances Tolerability and Pharmacokinetics in Rats

Geldanamycin (GA) and its analogues inhibit heat shock protein 90 (Hsp90) and have shown significant antitumor activity in vivo; however, clinical development of GA has been hampered by its poor solubility and severe hepatotoxicity. More soluble analogues, such as 17-DMAG and 17-AAG, are easier to f...

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Main Authors: Xiong, May P., Yáñez, Jaime A., Remsberg, Connie M., Ohgami, Yusuke, Kwon, Glen S., Davies, Neal M., Forrest, M. Laird
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492396/
https://ncbi.nlm.nih.gov/pubmed/18456363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.03.015
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