Enhanced Anticancer Activity of 5’-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs

The compound 5’-deoxy-5-fluorouridine (5’-DFUR) is a prodrug of the anti-tumor drug 5-fluorouracil (5-FU). Thymidine phosphorylase (TP) is an enzyme that can convert 5’-DFUR to its active form 5-FU and the expression of TP is upregulated in various cancer cells. In this study, 5’-DFUR associated wit...

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Bibliographic Details
Published in:Nanomaterials (Basel)
Main Authors: Sawdon, Alicia J., Zhang, Jun, Wang, Xutu, Peng, Ching-An
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315712/
https://ncbi.nlm.nih.gov/pubmed/30551585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano8121041
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