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Stereocomplex Prodrugs of Oligo(lactic acid)(n)‑Gemcitabine in Poly(ethylene glycol)-block-poly(D,L‑lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy
Herein we demonstrate the formation of stereo-complex prodrugs of oligo(L-lactic acid)(n)-gemcitabine (o(LLA)(n-)GEM) and oligo(D-lactic acid)(n)-gemcitabine (o(DLA)(n)-GEM) for stable incorporation in poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles. O(LLA)(n) or o(DLA)(n) was...
Guardat en:
| Publicat a: | ACS Nano |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071312/ https://ncbi.nlm.nih.gov/pubmed/29957934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b04205 |
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