Stereocomplex Prodrugs of Oligo(lactic acid)(n)‑Gemcitabine in Poly(ethylene glycol)-block-poly(D,L‑lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy

Herein we demonstrate the formation of stereo-complex prodrugs of oligo(L-lactic acid)(n)-gemcitabine (o(LLA)(n-)GEM) and oligo(D-lactic acid)(n)-gemcitabine (o(DLA)(n)-GEM) for stable incorporation in poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles. O(LLA)(n) or o(DLA)(n) was...

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Bibliographic Details
Published in:ACS Nano
Main Authors: Tam, Yu Tong, Huang, Chengbin, Poellmann, Michael, Kwon, Glen S.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071312/
https://ncbi.nlm.nih.gov/pubmed/29957934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b04205
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