An allosteric ligand-binding site in the extracellular cap of K2P channels

Two-pore domain potassium (K2P) channels generate leak currents that are responsible for the maintenance of the resting membrane potential, and they are thus potential drug targets for treating diseases. Here, we identify N-(4-cholorphenyl)-N-(2-(3,4-dihydrosioquinolin-2(1H)-yl)-2-oxoethyl)methanesu...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Luo, Qichao, Chen, Liping, Cheng, Xi, Ma, Yuqin, Li, Xiaona, Zhang, Bing, Li, Li, Zhang, Shilei, Guo, Fei, Li, Yang, Yang, Huaiyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575254/
https://ncbi.nlm.nih.gov/pubmed/28851868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00499-3
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