Extracellular Calcium Modulates Actions of Orthosteric and Allosteric Ligands on Metabotropic Glutamate Receptor 1α

Metabotropic glutamate receptor 1α (mGluR1α), a member of the family C G protein-coupled receptors, is emerging as a potential drug target for various disorders, including chronic neuronal degenerative diseases. In addition to being activated by glutamate, mGluR1α is also modulated by extracellular...

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Detalhes bibliográficos
Main Authors: Jiang, Jason Y., Nagaraju, Mulpuri, Meyer, Rebecca C., Zhang, Li, Hamelberg, Donald, Hall, Randy A., Brown, Edward M., Conn, P. Jeffrey, Yang, Jenny J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894344/
https://ncbi.nlm.nih.gov/pubmed/24280223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507665
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