An allosteric ligand-binding site in the extracellular cap of K2P channels

Two-pore domain potassium (K2P) channels generate leak currents that are responsible for the maintenance of the resting membrane potential, and they are thus potential drug targets for treating diseases. Here, we identify N-(4-cholorphenyl)-N-(2-(3,4-dihydrosioquinolin-2(1H)-yl)-2-oxoethyl)methanesu...

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Publicado en:Nat Commun
Autores principales: Luo, Qichao, Chen, Liping, Cheng, Xi, Ma, Yuqin, Li, Xiaona, Zhang, Bing, Li, Li, Zhang, Shilei, Guo, Fei, Li, Yang, Yang, Huaiyu
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575254/
https://ncbi.nlm.nih.gov/pubmed/28851868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00499-3
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