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DeSUMOylation of Gli1 by SENP1 Attenuates Sonic Hedgehog Signaling

The transcriptional output of the Sonic Hedgehog morphogenic pathway is orchestrated by three Krüppel family transcription factors, Gli1 to -3, which undergo extensive posttranslational modifications, including ubiquitination and SUMOylation. Here, we report that the sentrin-specific peptidase SENP1...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Liu, Huaize, Yan, Sen, Ding, Jie, Yu, Ting-Ting, Cheng, Steven Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574045/
https://ncbi.nlm.nih.gov/pubmed/28630282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00579-16
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