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Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception
Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two ‘PPXY’ motifs, that...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4080449/ https://ncbi.nlm.nih.gov/pubmed/24925320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02555 |
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