Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

Patched (Ptc) is the ligand-binding component of the Hedgehog (Hh) receptor complex. In the Drosophila embryo, Ptc and Hh colocalize in vesicular punctate structures. However, receptor-mediated endocytosis of Hh proteins has not been demonstrated. By using chick neural plate explants, we show that S...

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Библиографические подробности
Главные авторы: Incardona, John P., Lee, Ju Ho, Robertson, Christie P., Enga, Kristi, Kapur, Raj P., Roelink, Henk
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2000
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC17291/
https://ncbi.nlm.nih.gov/pubmed/11027307
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