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Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life

Sonic Hedgehog (Shh) coordinates Zn(2+) in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn(2+) coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. Th...

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Bibliografiska uppgifter
I publikationen:J Dev Biol
Huvudupphovsman: Roelink, Henk
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027127/
https://ncbi.nlm.nih.gov/pubmed/29890674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jdb6020012
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