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Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life
Sonic Hedgehog (Shh) coordinates Zn(2+) in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn(2+) coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. Th...
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| Pubblicato in: | J Dev Biol |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6027127/ https://ncbi.nlm.nih.gov/pubmed/29890674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jdb6020012 |
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