Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides()

Phenotypic whole-cell screening in erythrocytic co-cultures of Plasmodium falciparum identified a series of dihydroisoquinolones that possessed potent anti-malarial activity against multiple resistant strains of P. falciparum in vitro and show no cytotoxicity to mammalian cells. Systematic structure...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Floyd, David M., Stein, Philip, Wang, Zheng, Liu, Jian, Castro, Steve, Clark, Julie A., Connelly, Michele, Zhu, Fangyi, Holbrook, Gloria, Matheny, Amy, Sigal, Martina S., Min, Jaeki, Dhinakaran, Rajkumar, Krishnan, Senthil, Bashyum, Sridevi, Knapp, Spencer, Guy, R. Kiplin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573263/
https://ncbi.nlm.nih.gov/pubmed/27505686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00752
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