Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides()

Phenotypic whole-cell screening in erythrocytic co-cultures of Plasmodium falciparum identified a series of dihydroisoquinolones that possessed potent anti-malarial activity against multiple resistant strains of P. falciparum in vitro and show no cytotoxicity to mammalian cells. Systematic structure...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Floyd, David M., Stein, Philip, Wang, Zheng, Liu, Jian, Castro, Steve, Clark, Julie A., Connelly, Michele, Zhu, Fangyi, Holbrook, Gloria, Matheny, Amy, Sigal, Martina S., Min, Jaeki, Dhinakaran, Rajkumar, Krishnan, Senthil, Bashyum, Sridevi, Knapp, Spencer, Guy, R. Kiplin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573263/
https://ncbi.nlm.nih.gov/pubmed/27505686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00752
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