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Synthesis and Structure-Activity Relationships of Antimalarial 4-oxo-3-carboxyl quinolones

Malaria is endemic in tropical and subtropical regions of Africa, Asia, and the Americas. The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs. In this light, novel scaffolds to which the parasite has not been e...

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Bibliografiske detaljer
Main Authors: Zhang, Yiqun, Guiguemde, W. Armand, Sigal, Martina, Zhu, Fangyi, Connelly, Michele C., Nwaka, Solomon, Guy, R. Kiplin
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850272/
https://ncbi.nlm.nih.gov/pubmed/20206533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.013
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