Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations

Characterization of the second nucleotide-binding domain (NBD2) of the cystic fibrosis transmembrane conductance regulator (CFTR) has lagged behind research into the NBD1 domain, in part because NBD1 contains the F508del mutation, which is the dominant cause of cystic fibrosis. Research on NBD2 has...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vernon, Robert M., Chong, P. Andrew, Lin, Hong, Yang, Zhengrong, Zhou, Qingxian, Aleksandrov, Andrei A., Dawson, Jennifer E., Riordan, John R., Brouillette, Christie G., Thibodeau, Patrick H., Forman-Kay, Julie D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572908/
https://ncbi.nlm.nih.gov/pubmed/28655774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772335
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