Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

Deletion of Phe-508 (F508del) in the first nucleotide binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to defects in folding and channel gating. NMR data on human F508del NBD1 indicate that an H620Q mutant, shown to increase channel open probability, and...

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Detalhes bibliográficos
Main Authors: Hudson, Rhea P., Chong, P. Andrew, Protasevich, Irina I., Vernon, Robert, Noy, Efrat, Bihler, Hermann, An, Jian Li, Kalid, Ori, Sela-Culang, Inbal, Mense, Martin, Senderowitz, Hanoch, Brouillette, Christie G., Forman-Kay, Julie D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436552/
https://ncbi.nlm.nih.gov/pubmed/22722932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371138
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