Yüklüyor......

Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

Deletion of Phe-508 (F508del) in the first nucleotide binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to defects in folding and channel gating. NMR data on human F508del NBD1 indicate that an H620Q mutant, shown to increase channel open probability, and...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Hudson, Rhea P., Chong, P. Andrew, Protasevich, Irina I., Vernon, Robert, Noy, Efrat, Bihler, Hermann, An, Jian Li, Kalid, Ori, Sela-Culang, Inbal, Mense, Martin, Senderowitz, Hanoch, Brouillette, Christie G., Forman-Kay, Julie D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436552/
https://ncbi.nlm.nih.gov/pubmed/22722932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371138
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!