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Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization

Deletion of Phe-508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) results in destabilization of the domain, intramolecular interactions involving the domain, and the entire channel. The destabilization caused by F508del mani...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Chong, P. Andrew, Farber, Patrick J., Vernon, Robert M., Hudson, Rhea P., Mittermaier, Anthony K., Forman-Kay, Julie D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645629/
https://ncbi.nlm.nih.gov/pubmed/26149808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641134
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