Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization

Deletion of Phe-508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) results in destabilization of the domain, intramolecular interactions involving the domain, and the entire channel. The destabilization caused by F508del mani...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chong, P. Andrew, Farber, Patrick J., Vernon, Robert M., Hudson, Rhea P., Mittermaier, Anthony K., Forman-Kay, Julie D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645629/
https://ncbi.nlm.nih.gov/pubmed/26149808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641134
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