Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Folding correctors of F508del-CFTR were discovered by in silico structure-based screening utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and three cavities were identified at inter-domain interfaces: (1) Interface between the two Nucleotide Binding Domains (NBDs); (...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kalid, Ori, Mense, Martin, Fischman, Sharon, Shitrit, Alina, Bihler, Hermann, Ben-Zeev, Efrat, Schutz, Nili, Pedemonte, Nicoletta, Thomas, Philip J., Bridges, Robert J., Wetmore, Diana R., Marantz, Yael, Senderowitz, Hanoch
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010227/
https://ncbi.nlm.nih.gov/pubmed/20976528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-010-9390-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados