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Pharmacological Correctors of Mutant CFTR Mistrafficking
The lack of phenylalanine 508 (ΔF508 mutation) in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl(−) channel represents the most frequent cause of CF, a genetic disease affecting multiple organs such as lung, pancreas, and liver. ΔF508 causes instability and misfolding of CFTR...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Research Foundation
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464431/ https://ncbi.nlm.nih.gov/pubmed/23060795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00175 |
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