Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Linear peptides containing the sequence WKTSRTSHY were used as lead compounds to synthesize a novel peptidomimetic antagonist of α2β1 integrin, with platelet aggregation-inhibiting activity, named Vipegitide. Vipegitide is a 13-amino acid, folded peptidomimetic molecule, containing two α-aminoisobut...

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Библиографические подробности
Опубликовано в: :Drug Des Devel Ther
Главные авторы: Momic, Tatjana, Katzhendler, Jehoshua, Shai, Ela, Noy, Efrat, Senderowitz, Hanoch, Eble, Johannes A, Marcinkiewicz, Cezary, Varon, David, Lazarovici, Philip
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2015
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294129/
https://ncbi.nlm.nih.gov/pubmed/25609915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S72844
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