Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

A novel stress-inducible protein, Sestrin2 (Sesn2), declines in the heart with aging. AMPK has emerged as a pertinent stress-activated kinase that has been shown to have cardioprotective capabilities against myocardial ischemic injury. We identified the interaction between Sesn2 and AMPK in the isch...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Quan, Nanhu, Sun, Wanqing, Wang, Lin, Chen, Xu, Bogan, Jonathan S., Zhou, Xinchun, Cates, Courtney, Liu, Quan, Zheng, Yang, Li, Ji
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572689/
https://ncbi.nlm.nih.gov/pubmed/28592638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700063R
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