Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and reperfusion (I/R) insults. We hypothesize that Sesn2 as a scaffold protein maint...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Ren, Di, He, Zhibin, Fedorova, Julia, Zhang, Jingwen, Wood, Elizabeth, Zhang, Xiang, Kang, David E., Li, Ji
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734306/
https://ncbi.nlm.nih.gov/pubmed/33316744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101824
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