Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and reperfusion (I/R) insults. We hypothesize that Sesn2 as a scaffold protein maint...

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Enregistré dans:
Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Ren, Di, He, Zhibin, Fedorova, Julia, Zhang, Jingwen, Wood, Elizabeth, Zhang, Xiang, Kang, David E., Li, Ji
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734306/
https://ncbi.nlm.nih.gov/pubmed/33316744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101824
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