Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and reperfusion (I/R) insults. We hypothesize that Sesn2 as a scaffold protein maint...

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Bibliographische Detailangaben
Veröffentlicht in:Redox Biol
Hauptverfasser: Ren, Di, He, Zhibin, Fedorova, Julia, Zhang, Jingwen, Wood, Elizabeth, Zhang, Xiang, Kang, David E., Li, Ji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734306/
https://ncbi.nlm.nih.gov/pubmed/33316744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101824
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