SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism that medicated inflammatory response during ischemia and reperfusion (I/R...

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Pubblicato in:Redox Biol
Autori principali: Han, Ying, Sun, Weiju, Ren, Di, Zhang, Jingwen, He, Zhibin, Fedorova, Julia, Sun, Xiaodong, Han, Fang, Li, Ji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176991/
https://ncbi.nlm.nih.gov/pubmed/32325423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101538
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