PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis

The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-1α cofactor is controversial and remains unknown in skeletal tissues. We investigated whether PHD3 controls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (PKM)-2-Jumonji doma...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:FASEB J
Hlavní autoři: Schoepflin, Zachary R., Silagi, Elizabeth S., Shapiro, Irving M., Risbud, Makarand V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572688/
https://ncbi.nlm.nih.gov/pubmed/28495754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601291R
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky