Bicarbonate Recycling by HIF-1-dependent Carbonic Anhydrase isoforms 9 and 12 is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells

Intervertebral disc degeneration is a ubiquitous condition closely linked to chronic low-back pain. The health of the avascular nucleus pulposus (NP) plays a crucial role in the development of this pathology. We tested the hypothesis that a network comprising HIF-1α, Carbonic anhydrase (CA) 9 and 12...

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Vydáno v:J Bone Miner Res
Hlavní autoři: Silagi, Elizabeth S., Schoepflin, Zachary R., Seifert, Erin L., Merceron, Christophe, Schipani, Ernestina, Shapiro, Irving M., Risbud, Makarand V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947995/
https://ncbi.nlm.nih.gov/pubmed/28940640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3293
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