Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

Nucleus pulposus (NP) cells reside in the avascular and hypoxic microenvironment of intervertebral discs. Importantly, many activities related to survival and function of NP cells are controlled by the HIF-family of transcription factors. We hypothesize that NP cells adapt to their hypoxic niche thr...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Choi, Hyowon, Merceron, Christophe, Mangiavini, Laura, Seifert, Erin L., Schipani, Ernestina, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082780/
https://ncbi.nlm.nih.gov/pubmed/27314664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1192753
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