Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

The intervertebral disc (IVD) is one of the largest avascular organs in vertebrates. The nucleus pulposus (NP), a highly hydrated and proteoglycan-enriched tissue, forms the inner portion of the IVD. The NP is surrounded by a multi-lamellar fibrocartilaginous structure, the annulus fibrosus (AF). Th...

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Main Authors: Merceron, Christophe, Mangiavini, Laura, Robling, Alexander, Wilson, Tremika LeShan, Giaccia, Amato J., Shapiro, Irving M., Schipani, Ernestina, Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206488/
https://ncbi.nlm.nih.gov/pubmed/25338007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110768
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