Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assay (CiPA) was proposed to improve prediction of TdP...

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Detaylı Bibliyografya
Yayımlandı:Front Physiol
Asıl Yazarlar: Dutta, Sara, Chang, Kelly C., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Wendy W., Wu, Min, Strauss, David G., Colatsky, Thomas, Li, Zhihua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Physiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572155/
https://ncbi.nlm.nih.gov/pubmed/28878692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00616
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