Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assay (CiPA) was proposed to improve prediction of TdP...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Dutta, Sara, Chang, Kelly C., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Wendy W., Wu, Min, Strauss, David G., Colatsky, Thomas, Li, Zhihua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572155/
https://ncbi.nlm.nih.gov/pubmed/28878692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00616
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