Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assay (CiPA) was proposed to improve prediction of TdP...

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Publicat a:Front Physiol
Autors principals: Dutta, Sara, Chang, Kelly C., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Wendy W., Wu, Min, Strauss, David G., Colatsky, Thomas, Li, Zhihua
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572155/
https://ncbi.nlm.nih.gov/pubmed/28878692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00616
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