Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic assays. Under the CiPA paradigm, the relative risk of drug-induced Torsade de Pointes (TdP) is assessed using an in silico model of...

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Foilsithe in:Front Physiol
Main Authors: Chang, Kelly C., Dutta, Sara, Mirams, Gary R., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Min, Wu, Wendy W., Colatsky, Thomas, Strauss, David G., Li, Zhihua
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2017
Ábhair:
Physiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702340/
https://ncbi.nlm.nih.gov/pubmed/29209226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00917
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