Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates multi‐ion channel pharmacology data in vitr...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Li, Zhihua, Ridder, Bradley J., Han, Xiaomei, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Randolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492074/
https://ncbi.nlm.nih.gov/pubmed/30151907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1184
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